Leaders from Europe and the US convened to explore exciting leaps forward of AI in oncology at the HIMSS21 & Health 2.0 European Health Conference, though the panel highlighted key barriers to greater acceptance and adoption of AI into mainstream care. The'New Frontiers of AI and Data Analytics in Oncology' session, moderated by Professor Karol Sikora, chief medical officer, Rutherford Health and former chief of the Cancer Programme, WHO, also saw leaders share innovative applications for AI used across the cancer pathway. The panel of experts also included Professor Barbara Alicja Jereczek-Fossa, associate professor of Radiation Oncology, University of Milan and head of Radiotherapy Division, European Institute of Oncology, and her colleague, Eng. Joining from the US was Dr Tufia Haddad, chair of Digital Health, Department of Oncology, Mayo Clinic and chair of Practice Innovation and Platform, Mayo Clinic Cancer Center. While AI is already widely used in oncology in image analysis and other areas, exciting new applications are being trialled at leading cancer centres across the globe.